Neonatal Research
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Since the foundation of the neonatal research group in Innsbruck several projects have been performed. The results have been presented at national and international meetings and have been published in peer reviewed journals.


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Articles 2020

Posod A, Winkler I, Wegleiter K, Huber E, Urbanek M, Kiechl-Kohlendorfer U, Griesmaier E.
The effect of levomepromazine on the healthy and injured developing mouse brain - An in vitro and in vivo study.
IBRO Rep. 2020 Sep 24;9:247-257. doi: 10.1016/j.ibror.2020.09.003. eCollection 2020 Dec.
Stevenson NJ, Tataranno ML, Kaminska A, Pavlidis E, Clancy RR, Griesmaier E, Roberts JA, Klebermass-Schrehof K, Vanhatalo S.
Reliability and accuracy of EEG interpretation for estimating age in preterm infants.
Ann Clin Transl Neurol. 2020 Aug 7;7(9):1564-73. doi: 10.1002/acn3.51132.
Pechlaner R, Posod A, Yin X, Burnap SA, Kiechl SJ, Mayr M, Kiechl S, Kiechl-Kohlendorfer U.
Very preterm birth results in later lower platelet activation markers.
Pediatr Res. 2020 Jul 22. doi: 10.1038/s41390-020-1070-8.
Hammerl M, Zagler M, Zimmermann M, Griesmaier E, Janjic T, Gizewski ER, Kiechl-Kohlendorfer U, Neubauer V.
Supratentorial Brain Metrics Predict Neurodevelopmental Outcome in Very Preterm Infants without Brain Injury at Age 2 Years.
Neonatology. 2020 May 12:1-7. doi: 10.1159/000506836.
Posod A, Schaefer B, Mueller T, Zoller H, Kiechl-Kohlendorfer U.
Hypophosphatemia in children treated with ferric carboxymaltose. 
Acta Paediatr. 2020 Jul;109(7):1491-1492. doi: 10.1111/apa.15178. Epub 2020 Jan 28.
Burger C, Hammerl M, Neubauer V, Pupp Peglow U, Kiechl-Kohlendorfer U, Griesmaier E.
Early preterm infants with abnormal psychomotor neurodevelopmental outcome at age two show alterations in amplitude-integrated electroencephalography signals.
Early Hum Dev. 2020 Feb;141:104935. doi: 10.1016/j.earlhumdev.2019.104935. Epub 2019 Dec 10.
Hammerl M, Zagler M, Griesmaier E, Janjic T, Gizewski ER, Kiechl-Kohlendorfer U, Neubauer V.
Reduced Cerebellar Size at Term-Equivalent Age Is Related to a 17% Lower Mental Developmental Index in Very Preterm Infants without Brain Injury.
Neonatology. 2020;117(1):57-64. doi: 10.1159/000502491. Epub 2019 Sep 3.

Articles 2019

Burger C, Hammerl M, Neubauer V, Pupp Peglow U, Kiechl-Kohlendorfer U, Griesmaier E.
Early preterm infants with abnormal psychomotor neurodevelopmental outcome at age two show alterations in amplitude-integrated electroencephalography signals.
Early Hum Dev. 2020 Feb;141:104935. doi: 10.1016/j.earlhumdev.2019.104935. Epub 2019 Dec 10.
Resch M, Bresele S, Kager K, Pupp Peglow U, Griesmaier E, Kiechl-Kohlendorfer U.
Predictors for delayed linguistic skills in very preterm infants.
J Neonatal Perinatal Med. 2019;12(4):465-472. doi: 10.3233/NPM-1838.
Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U.
Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children.
J Am Heart Assoc. 2019 Apr 16;8(8):e011199. doi: 10.1161/JAHA.118.011199.
Posod A, Wechselberger K, Schmid A, Huber E, Urbanek M, Kiechl-Kohlendorfer U, Griesmaier E.
Excitotoxicity Alters Endogenous Secretoneurin Plasma Levels, but Supplementation with Secretoneurin Does Not Protect Against Excitotoxic Neonatal Brain Injury.
Neuroscience. 2019 Jul 1;410:239-253. doi: 10.1016/j.neuroscience.2019.05.023. Epub 2019 May 21.
Posod A, Wegleiter K, Neubauer V, Urbanek M, Huber E, Kiechl-Kohlendorfer U, Keller M, Griesmaier E.
Short-, Mid-, and Long-Term Effect of Granulocyte Colony-Stimulating Factor/Stem Cell Factor and Fms-Related Tyrosine Kinase 3 Ligand Evaluated in an In Vivo Model of Hypoxic-Hyperoxic Ischemic Neonatal Brain Injury.
Biomed Res Int. 2019 Mar 13;2019:5935279. doi: 10.1155/2019/5935279. eCollection 2019.
Burger C, Biermayr M, Posod A, Neubauer V, Pupp Peglow U, Kuenz K, Kiechl-Kohlendorfer U, Griesmaier E.
Amplitude-integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills.
Acta Paediatr. 2019 Sep;108(9):1661-1668. doi: 10.1111/apa.14755. Epub 2019 Mar 10.

Articles 2018

Kiechl-Kohlendorfer U, Biermayr M, Pupp Peglow U, Griesmaier E.
Outcome of infants born at < 32 weeks` gestation in a single-centre level III neonatology unit - relation to feeding strategy.
J Int Med Res. 2018 Aug 29:300060518790706
Stock K, Schmid A, Griesmaier E, Gande N, Hochmayr C, Knoflach M, Kiechl-Kohlendorfer U; Early Vascular Aging (EVA) Study Group.
The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents.
J Pediatr. 2018 Jun 27. pii: S0022-3476(18)30769-8.
Neubauer V, Djurdjevic T, Griesmaier E, Biermayr M, Gizewski ER, Kiechl-Kohlendorfer U.
The Cerebellar-Cerebral Microstructure Is Disrupted at Multiple Sites in Very Preterm Infants with Cerebellar Haemorrhage.
Neonatology. 2018;113(2):93-99. doi: 10.1159/000480695.

Articles 2017

Posod A, Odri Komazec I, Pupp Peglow U, Meraner D, Griesmaier E, Kiechl-Kohlendorfer U.
Former Very Preterm Infants Show Alterations in Thyroid Function at a Preschool Age.
Biomed Res Int. 2017;2017:3805370. doi: 10.1155/2017/3805370. Epub 2017 Jul 19.
Posod A, Wechselberger K, Stanika RI, Obermair GJ, Wegleiter K, Huber E, Urbanek M, Kiechl-Kohlendorfer U, Griesmaier E.
Administration of secretoneurin is protective in hypoxic-ischemic neonatal brain injury predominantly in the hypoxic-only hemisphere.
Neuroscience. 2017 Apr 6. pii: S0306-4522(17)30230-0. doi: 10.1016/j.neuroscience.2017.03.055. 
Posod A, Müller S, Komazec IO, Dejaco D, Peglow UP, Griesmaier E, Scholl-Bürgi S, Karall D, Kiechl-Kohlendorfer U.
Former very preterm infants show alterations in plasma amino acid profiles at a preschool age. 
Pediatr Res. 2017 Mar 22. doi: 10.1038/pr.2017.24. 
Ralser E, Neubauer V, Pupp-Peglow U, Kiechl-Kohlendorfer U, Griesmaier E.
Amplitude-integrated electroencephalography can predict neurodevelopmental outcome at 12 months of corrected age in very preterm infants.
Acta Paediatr. 2017 Jan 20.
Neubauer V, Djurdjevic T, Griesmaier E, Biermayr M, Gizewski ER, Kiechl-Kohlendorfer U.
Routine Magnetic Resonance Imaging at Term-Equivalent Age Detects Brain Injury in 25% of a Contemporary Cohort of Very Preterm Infants.
PLoS One. 2017 Jan 3;12(1):e0169442.

Articles 2016

Posod A, Odri Komazec I, Kager K, Pupp Peglow U, Griesmaier E, Schermer E, Würtinger P, Baumgartner D, Kiechl-Kohlendorfer U.
Former Very Preterm Infants Show an Unfavorable Cardiovascular Risk Profile at a Preschool Age.
PLoS One. 2016 Dec 13;11(12):e0168162.
Wechselberger K, Schmid A, Posod A, Höck M, Neubauer V, Fischer-Colbrie R, Kiechl-Kohlendorfer U, Griesmaier E.
Secretoneurin Serum Levels in Healthy Term Neonates and Neonates with Hypoxic-Ischaemic Encephalopathy.
Neonatology. 2016 Mar 12;110(1):14-20.
Neubauer V, Fuchs T, Griesmaier E, Kager K, Pupp Peglow U, Kiechl-Kohlendorfer U.
Poor post-discharge head growth is related to a 10% lower intelligence quotient in very preterm infants at the chronological age of five years.
Acta Paediatr. 2016 Jan 21. doi: 10.1111/apa.13336.
Neubauer V, Wegleiter K, Posod A, Urbanek M, Wechselberger K, Kiechl-Kohlendorfer U, Keller M, Griesmaier E.
Delayed application of the haematopoietic growth factors G-CSF/SCF and FL reduces neonatal excitotoxic brain injury.
Brain Res. 2016 Jan 6. pii: S0006-8993(15)00997-X. doi: 10.1016/j.brainres.2015.12.058.
Posod A, Griesmaier E, Brunner A, Pototschnig C, Trawöger R, Kiechl-Kohlendorfer U.
An unusual cause of inspiratory stridor in the newborn: congenital pharyngeal teratoma - a case report.
BMC Pediatr. 2016 Jan 5;16(1):1.

Articles 2015

Neubauer V, Fuchs T, Griesmaier E, Pupp-Peglow U, Kiechl-Kohlendorfer U.
Comparing growth charts demonstrated significant deviations between the interpretation of postnatal growth patterns in very preterm infants.
Acta Paediatr. 2015 Sep 2. doi: 10.1111/apa.13175.
Kiechl-Kohlendorfer U, Merkle U, Deufert D, Neubauer V, Pupp Peglow, Griesmaier E.
Effect of developmental care for very premature infants on neurodevelopmental outcome at 2 years of age.
Infant Behav Dev. 2015 May;39:166-72. doi: 10.1016/j.infbeh.2015.02.006. Epub 2015 Apr 9.
Griesmaier E, Burger C, Ralser E, Neubauer V, Kiechl-Kohlendorfer U.
Amplitude-integrated electroencephalography shows mild delays in electrocortical activity in preterm infants born small for gestational age.
Acta Paediatr. 2015 Feb 5.
Stock K, Griesmaier E, Grunner B, Neubauer V, Kiechl-Kohlendorfer U, Trawöger R.
Pasteurization of breast milk decreases the rate of postnatally acquired cytomegalovirus infections, but shows a non-significant trend to an increased rate of NEC in very preterm infants – a preliminary study.
Breastfeed Med. 2015 Feb 3.
Neubauer V, Junker D, Griesmaier E, Schocke M, Kiechl-Kohlendorfer U.
Bronchopulmonary dysplasia is associated with delayed structural brain maturation in preterm infants.
Neonatology. 2015;107(3):179-84.

Articles 2014

Binder E, Griesmaier E, Giner T, Sailer-Höck M, Brunner J.
Kawasaki disease in children and adolescents: clinical data of Kawasaki patients in a western region (Tyrol) of Austria from 2003–2012.
Pediatric Rheumatology 2014, 12:37  doi:10.1186/1546-0096-12-37.
Gnigler M, Neubauer V, Griesmaier E, Zotter S, Kager K, Kiechl-Kohlendorfer U.
Very preterm children risk reduced processing speed at five-years-of-age, predicted by typical complications of prematurity and prenatal smoking.
Acta Paediatr. 2014 Nov 10. doi: 10.1111/apa.12859.
Wegleiter K, Hermann M, Posod A, Wechselberger K, Stanika RI, Obermair GJ, Kiechl-Kohlendorfer U, Urbanek M, Griesmaier E.
The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo.
Exp Neurol. 2014 Aug 8;261C:501-509.
Posod A, Pinzer K, Urbanek M, Wegleiter K, Keller M, Kiechl-Kohlendorfer U, Griesmaier E.
The common antitussive agent dextromethorphan protects against hyperoxia-induced cell death in established in vivo and in vitro models of neonatal brain injury.
Neuroscience. 2014 Aug 22;274:260-72.
Griesmaier E, Stock K, Medek K, Stanika RI, Obermair GJ, Posod A, Wegleiter K, Urbanek M, Kiechl-Kohlendorfer U.
Levetiracetam increases neonatal hypoxic-ischemic brain injury under normothermic, but not hypothermic conditions.
Brain Res. 2014 Mar 27;1556:10-8.
Griesmaier E, Santuari E, Edlinger M, Neubauer V, Waltner-Romen M, Kiechl-Kohlendorfer U.
Differences in the Maturation of Amplitude-Integrated EEG Signals in Male and Female Preterm Infants.
Neonatology. 2014 Jan 10;105(3):175-181.

Articles 2013

Pocivalnik M, Meheden SV, Griesmaier E, Trawöger R, Kiechl-Kohlendorfer U, Pichler G, Reiterer F, Urlesberger B.
[Pneumothorax during Mechanical Ventilation - Therapeutic Options in Term and Preterm Neonates.]
Klin Padiatr. 2013 Oct 24.
Griesmaier E, Giner T, Posod A, Freund-Unsinn K, Trawöger R, Kiechl-Kohlendorfer U.
Clinical presentation and diagnostic work-up of isolated oesophageal lung in a neonate.Arch Dis Child Fetal Neonatal Ed. 2013 Sep 24. doi: 10.1136/archdischild-2013-304886.
Posod A, Krepp Y, Stock K, Urbanek M, Kiechl-Kohlendorfer U, Griesmaier E.
In vivo and in vitro evaluation of the effect of PRE-084 on inflammation-sensitized hyperoxia-induced developing brain injury.
J Neurosci Res. 2013 Aug 23. doi: 10.1002/jnr.23271.
Neubauer V, Griesmaier E, Pehböck-Walser N, Pupp-Peglow U, Kiechl-Kohlendorfer U.
Poor postnatal head growth in very preterm infants is associated with impaired neurodevelopment outcome.
Acta Paediatr. 2013 Jun 17. doi: 10.1111/apa.12319.

Articles 2012

Griesmaier E, Enot DP, Bachmann M, Neubauer V, Hellström-Westas L, Kiechl-Kohlendorfer U, Keller M.
Systematic characterization of amplitude-integrated EEG signals for monitoring the preterm brain.
Pediatr Res. 2012 Nov 22. doi: 10.1038/pr.2012.171.
Griesmaier E, Posod A, Gross M, Neubauer V, Wegleiter K, Hermann M, Urbanek M, Keller M, Kiechl-Kohlendorfer U.
Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice.
Exp Neurol. 2012 Jul 5.
Neubauer V, Griesmaier E, Ralser E, Kiechl-Kohlendorfer U,
The effect of sex on outcome of preterm infants - a population-based suvey.
Acta Paediatr. 2012 Apr 26.

Articles 2011

Neubauer V, Griesmaier E, Baumgartner K, Mallouhi A, Keller M, Kiechl-Kohlendorfer U.
Feasibility of cerebral MRI in non-sedated preterm born infants at term-equivalent age: Report of a single centre.
Acta Paediatr. 2011 Jun 21.
Griesmaier E, Keller M.
Glutamate receptors - Prenatal insults, long-term consequences.
Pharmacol Biochem Behav. 2012 Feb;100(4):835-40. Epub 2011 Apr 22. Review.
Griesmaier E, Neubauer V, Ralser E, Trawöger R, Kiechl-Kohlendorfer U, Keller M.
Need for quality control for aEEG monitoring of the preterm infant: a 2-year experience.
Acta Paediatr. 2011 Feb 25.

Articles 2010

Schlager GW, Griesmaier E, Wegleiter K, Neubauer V, Urbanek M, Kiechl-Kohlendorfer U, Felderhoff-Mueser U, Keller M.
Systemic G-CSF treatment does not improve long-term outcomes after neonatal hypoxic-ischaemic brain injury.
Exp Neurol. 2010 Dec 9.
Neubauer V, Griesmaier E, Trawoger R, Kiechl-Kohlendorfer U.
Congenital varicella syndrome in a very low birthweight preterm infant.
Arch Dis Child Fetal Neonatal Ed. 2010 Dec 7.
Griesmaier E, Neubauer V, Blum S, Trawöger R, Keller M, Kiechl-Kohlendorfer U.
Neurodevelopmental outcome following congenital cytomegalovirus infection in preterm infants with twin-to-twin transfusion syndrome: a case report.
Klin Padiatr. 2010 Sep;222(5):312-4.
Griesmaier E, Schlager G, Wegleiter K, Hermann M, Urbanek M, Simbruner G, Keller M.
Role of p75(NTR) in NMDAR-mediated excitotoxic brain injury in neonatal mice.
Brain Res. 2010 Oct 8;1355:31-40.
Keller M, Griesmaier E, Timischl M, Simbruner G.
Hypothermie in der Behandlung asphyktischer Neugeborener mit Hypoxisch-Ischämischer Enzephalopathie.
Kinder- und Jugendmedizin.
Steichen-Gersdorf E, Griesmaier E, Pientka FK, Kotzot D, Kutsche K.
A severe form of the X-linked microphthalmia with linear skin defects syndrome in a female newborn.
Clin Dysmorphol. 2010 Apr;19(2):82-4.
Kiechl-Kohlendorfer U, Ralser E, Pupp Peglow U, Reiter G, Griesmaier E, Trawöger R.
Smoking in pregnancy: a risk factor for adverse neurodevelopmental outcome in preterm infants?
Acta Paediatr. 2010 Jul;99(7):1016-9.

Articles 2009

Griesmaier E, Keller M.
Neuroprotective strategies in excitotoxic brain injury: potential applications to the preterm brain.
Future Neurology, July 2009, Vol. 4, No. 4, Pages 469-481.

Articles 2008

Doverhag C, Keller M, Karlsson A, Hedtharn M, Nilsson U, Kapeller E, Sárközy G, Klimaschweski L, Humpel C, Hagberg H, Simbruner G, Gressens P, Savman K.
Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice.
Neurobiology of Dis. 2008 Jul;31(1):133-44.
Keller M, Griesmaier E, Auer M, Urbanek M, Schlager G, Simbruner G, Gressens P, Sárközy G.
Dextromethorphan is protective against sensitized NMDAR - mediated excitotoxic brain damage in the developing mouse brain.
Eur J Neurosci. 2008 Feb;27(4):874-83.

Keller M, Scholl S, Sergi C, Theurl I, Weiss G, Unsinn KM, Müller T, Trawöger R.
An unusal case of intrauterine symptomatic neonatal liver failure.

Klin. Paediatr. 2008, Jan-Feb; 220 (1): 32-6.


Articles 2007

Sarkozy G, Griesmaier E, He X, Kapelari K, Urbanek M, Simbruner G, Gressens P, Keller M.
T3 replacement does not prevent excitotoxic cell death but reduces developmental neuronal apoptosis in newborn mice.
Eur J Paediatr Neurol. 2007 May; 11(3):129-35.
Krötz F, Keller M, Derflinger S, Schmid H, Gloe T, Bassermann F, Duyster J, Cohen CD, Schuhmann C, Klauss V, Pohl U, Stempfle HU, Sohn HY.
Mycophenolate Acid Inhibits Endothelial NAD(P)H Oxidase Activity and Superoxide Formation by a Rac1-Dependent Mechanism.
Hypertension. 2007 Jan;49(1):201-8.

Articles 2006

Keller M, Yang J, Griesmaier E, Gorna A, Sarkozy G, Urbanek M, Gressens P, Simbruner G.
Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice.
Neurobiol Dis. 2006 Nov;24(2):357-66.
Keller M, Simbruner G, Górna A, Urbanek M, Tinhofer I, Griesmaier E, Sarkozy G, Schwendimann L, Gressens P.
Systemic application of granulocyte-colony stimulating factor and stem cell factor exacerbates excitotoxic brain injury in newborn mice.
Pediatr Res. 2006 Apr;59(4 Pt 1):549-53.
Keller M, Lidington D, Vogel L, Peter BF, Sohn HY, Pagano PJ, Pitson S, Spiegel S, Pohl U, Bolz SS.
Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries.
FASEB J. 2006 Apr;20(6):702-4. Epub 2006 Feb 13.
Shouman B, Fontaine RH, Baud O, Schwendimann L, Keller M, Spedding M, Lelièvre V, Gressens P.
Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage.
Br J Pharmacol. 2006 Jun;148(4):442-51.
Timischl M, Simbruner G.
Asphyxie des Neugeborenen – Pathophysiologie, klinische Korrelate und Therapiemöglichkeiten.
Pädiatrische Praxis. 3:66, 2005
Timischl M, Simbruner G.
Management der perinatalen Asphyxie: Therapeutische Möglichkeiten anhand der pathophysiologischen Mechanismen.
Pädiatrie und Pädologie. 5, 2004.


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